The oldest prayer we know of dedicated to the Virgin Mary is known as "Beneath thy compassion" (Greek: Ὑπὸ τὴν σὴν εὐσπλαγχνίαν; Latin: Sub tuum praesidium).
The earliest text of this hymn was found in a Christmas liturgy of the third century.
It is written in Greek and dates to approximately 250 A.D.
For Orthodox, the hymn is sung as the last dismissal hymn of daily Vespers during Great Lent.
The entire hymn in Greek reads:
Ὑπὸ τὴν σὴν εὐσπλαγχνίαν,
Τὰς ἡμῶν ἱκεσίας,
μὴ παρίδῃς ἐν περιστάσει,
ἀλλ᾽ ἐκ κινδύνων λύτρωσαι ἡμᾶς,
μόνη Ἁγνή, μόνη εὐλογημένη.
Beneath thy compassion,
We take refuge, O Mother of God:
do not despise our petitions in time of trouble,
but rescue us from dangers,
only pure one, only blessed one.